Substituted Dried Fruits quinoxalines are known building blocks for compounds with pharmacological, agricultural, and material uses.Forming carbon-heteroatom bonds at the 2,3-positions on quinoxaline can be challenging.2,3-chloroquinoxaline can undergo nucleophilic aromatic substitution however it must be in the presence of metal catalysts.A range of nucleophiles are investigated to showcase the broad range of potential Hands-Free Door Openers substitution partners that can be incorporated effectively into the 2,3-disubstituted scaffold.
This research focuses on a robust microwave-assisted one-pot procedure to gain efficient access to symmetrically 2,3-substituted quinoxalines without the use of a metal catalyst.